NPC2 Facilitates Bidirectional Transfer of Cholesterol between NPC1 and Lipid Bilayers, a Step in Cholesterol Egress from Lysoso
![NPC2 facilitates bidirectional transfer of cholesterol between NPC1 and lipid bilayers, a step in cholesterol egress from lysosomes | PNAS NPC2 facilitates bidirectional transfer of cholesterol between NPC1 and lipid bilayers, a step in cholesterol egress from lysosomes | PNAS](https://www.pnas.org/cms/10.1073/pnas.0807328105/asset/62702758-adb3-4979-a862-91f9963a9503/assets/graphic/zpq9990848420006.jpeg)
NPC2 facilitates bidirectional transfer of cholesterol between NPC1 and lipid bilayers, a step in cholesterol egress from lysosomes | PNAS
![Structures of NPC1, NPC2 and PTCH proteins. A, NPC1 bound to NPC2 (24).... | Download Scientific Diagram Structures of NPC1, NPC2 and PTCH proteins. A, NPC1 bound to NPC2 (24).... | Download Scientific Diagram](https://www.researchgate.net/publication/331044445/figure/fig1/AS:743676556886016@1554317716256/Structures-of-NPC1-NPC2-and-PTCH-proteins-A-NPC1-bound-to-NPC2-24-Lumenal-domains.jpg)
Structures of NPC1, NPC2 and PTCH proteins. A, NPC1 bound to NPC2 (24).... | Download Scientific Diagram
Characterization of a Spontaneous Novel Mutation in the NPC2 Gene in a Cat Affected by Niemann Pick Type C Disease | PLOS ONE
![Lipids on Trial: The Search for the Offending Metabolite in Niemann‐Pick type C Disease - Lloyd‐Evans - 2010 - Traffic - Wiley Online Library Lipids on Trial: The Search for the Offending Metabolite in Niemann‐Pick type C Disease - Lloyd‐Evans - 2010 - Traffic - Wiley Online Library](https://onlinelibrary.wiley.com/cms/asset/51adbb9c-61b5-4456-8b84-af1aa6226374/tra_1032_f5.gif)
Lipids on Trial: The Search for the Offending Metabolite in Niemann‐Pick type C Disease - Lloyd‐Evans - 2010 - Traffic - Wiley Online Library
![Clues to the mechanism of cholesterol transfer from the structure of NPC1 middle lumenal domain bound to NPC2 | PNAS Clues to the mechanism of cholesterol transfer from the structure of NPC1 middle lumenal domain bound to NPC2 | PNAS](https://www.pnas.org/cms/10.1073/pnas.1611956113/asset/aed497a9-fb94-483b-81b7-9c1f5ec8cde6/assets/graphic/pnas.1611956113fig05.jpeg)
Clues to the mechanism of cholesterol transfer from the structure of NPC1 middle lumenal domain bound to NPC2 | PNAS
![The GARP Complex Is Involved in Intracellular Cholesterol Transport via Targeting NPC2 to Lysosomes - ScienceDirect The GARP Complex Is Involved in Intracellular Cholesterol Transport via Targeting NPC2 to Lysosomes - ScienceDirect](https://ars.els-cdn.com/content/image/1-s2.0-S2211124717308082-fx1.jpg)
The GARP Complex Is Involved in Intracellular Cholesterol Transport via Targeting NPC2 to Lysosomes - ScienceDirect
![IJMS | Free Full-Text | Simulations of NPC1(NTD):NPC2 Protein Complex Reveal Cholesterol Transfer Pathways IJMS | Free Full-Text | Simulations of NPC1(NTD):NPC2 Protein Complex Reveal Cholesterol Transfer Pathways](https://www.mdpi.com/ijms/ijms-19-02623/article_deploy/html/images/ijms-19-02623-g010.png)
IJMS | Free Full-Text | Simulations of NPC1(NTD):NPC2 Protein Complex Reveal Cholesterol Transfer Pathways
![NPC1 regulates ER contacts with endocytic organelles to mediate cholesterol egress | Nature Communications NPC1 regulates ER contacts with endocytic organelles to mediate cholesterol egress | Nature Communications](https://media.springernature.com/lw685/springer-static/image/art%3A10.1038%2Fs41467-019-12152-2/MediaObjects/41467_2019_12152_Fig7_HTML.png)
NPC1 regulates ER contacts with endocytic organelles to mediate cholesterol egress | Nature Communications
![The cholesterol‐binding protein NPC2 restrains recruitment of stromal macrophage‐lineage cells to early‐stage lung tumours | EMBO Molecular Medicine The cholesterol‐binding protein NPC2 restrains recruitment of stromal macrophage‐lineage cells to early‐stage lung tumours | EMBO Molecular Medicine](https://www.embopress.org/cms/asset/143b9448-2823-4b3a-a940-bd69d927d5a4/emmm201404838-fig-0005-m.jpg)
The cholesterol‐binding protein NPC2 restrains recruitment of stromal macrophage‐lineage cells to early‐stage lung tumours | EMBO Molecular Medicine
![IJMS | Free Full-Text | Simulations of NPC1(NTD):NPC2 Protein Complex Reveal Cholesterol Transfer Pathways IJMS | Free Full-Text | Simulations of NPC1(NTD):NPC2 Protein Complex Reveal Cholesterol Transfer Pathways](https://www.mdpi.com/ijms/ijms-19-02623/article_deploy/html/images/ijms-19-02623-g001.png)
IJMS | Free Full-Text | Simulations of NPC1(NTD):NPC2 Protein Complex Reveal Cholesterol Transfer Pathways
Computational Studies of the Cholesterol Transport between NPC2 and the N-Terminal Domain of NPC1 (NPC1(NTD)) | Biochemistry
![Structural motifs of human NPC1 and HE1/NPC2 proteins. The NPC1 protein... | Download Scientific Diagram Structural motifs of human NPC1 and HE1/NPC2 proteins. The NPC1 protein... | Download Scientific Diagram](https://www.researchgate.net/publication/11253207/figure/fig3/AS:277251166883844@1443113237284/Structural-motifs-of-human-NPC1-and-HE1-NPC2-proteins-The-NPC1-protein-top-is.png)
Structural motifs of human NPC1 and HE1/NPC2 proteins. The NPC1 protein... | Download Scientific Diagram
![Expanded complement of Niemann-Pick type C2-like protein genes in Clonorchis sinensis suggests functions beyond sterol binding and transport | Parasites & Vectors | Full Text Expanded complement of Niemann-Pick type C2-like protein genes in Clonorchis sinensis suggests functions beyond sterol binding and transport | Parasites & Vectors | Full Text](https://media.springernature.com/lw685/springer-static/image/art%3A10.1186%2Fs13071-020-3910-0/MediaObjects/13071_2020_3910_Fig1_HTML.png)